SIV (isolate 216.94.A2) gp120 Protein, His Tag_天津卡梅德科技发展有限公司

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SIV (isolate 216.94.A2) gp120 Protein, His Tag

SIV (isolate 216.94.A2) gp120 Protein, His Tag

产品编号

KMP4909

别名

猴免疫缺陷病毒包膜蛋白gp120, SIV gp120, Envelope Protein gp120, SIV gp120 Protein

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	猴免疫缺陷病毒包膜蛋白gp120, SIV gp120, Envelope Protein gp120, SIV gp120 Protein
Catalog Number	KMP4909
Product Description	The SIV (isolate 216.94.A2) gp120 Protein(KMP4909) is produced in HEK293 Cells. A DNA sequence encoding the Simian immunodeficiency virus (isolate 216.94.A2) (ADN41251.1) (Ile20-Arg528) was expressed with a polyhistidine tag at the C-terminus.
Molecular Name	SIV gp120
Species	SIV
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>85% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.

FAQ

Q1-gp120在SIV感染中的作用是什么？

gp120是SIV表面糖蛋白，结合宿主CD4和趋化因子共受体（如CCR5），介导病毒入侵T细胞，是疫苗和药物开发的靶标。
Q2-该毒株的研究价值是什么？

分离自非洲绿猴的SIV 216.94.A2株，用于模拟HIV-1传播机制及评估疫苗交叉保护效果。
Q3-如何检测gp120的糖基化修饰？

使用PNGase F酶切后SDS-PAGE分析迁移率变化，或质谱鉴定N-糖基化位点（如Asn-332）。
Q4-能否用于HIV-1抗体交叉反应研究？

是的，SIV gp120与HIV-1 gp120具有结构相似性，可筛选广谱中和抗体（如V3环特异性抗体）。
Q5-His标签是否影响抗原性？

经ELISA和中和实验验证，标签位于C端，不影响与单克隆抗体（如b12）的结合。

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