EBOV (subtype Zaire, strain Ebola virus H.sapiens-wt/SLE/2014/ManoRiver-G3686.1) GP Protein, His Tag_天津卡梅德科技发展有限公司

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EBOV (subtype Zaire, strain Ebola virus H.sapiens-wt/SLE/2014/ManoRiver-G3686.1) GP Protein, His Tag

EBOV (subtype Zaire, strain Ebola virus H.sapiens-wt/SLE/2014/ManoRiver-G3686.1) GP Protein, His Tag

产品编号

KMP4461

别名

埃博拉病毒包膜糖蛋白, EBOV GP, Glycoprotein, EBOV GP Protein

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	埃博拉病毒包膜糖蛋白, EBOV GP, Glycoprotein, EBOV GP Protein
Catalog Number	KMP4461
Product Description	The EBOV (subtype Zaire, strain Ebola virus H.sapiens-wt/SLE/2014/ManoRiver-G3686.1) GP Protein(KMP4461) is produced in HEK293 Cells. A DNA sequence encoding the Zaire ebolavirus(strain Ebola virus H.sapiens-wt/SLE/2014/ManoRiver-G3686.1) GP (AIE11917.1) (Met1-Gln650) was expressed with a polyhistidine tag at the C-terminus.
Molecular Name	EBOV GP
Species	EBOV
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	20mM Tris, 500mM NaCl, 10% Glycerol, pH8.0
Background	Influenza viral nucleoprotein (NP) plays a critical role in virus replication and host adaptation. Nucleoprotein (NP) is an essential multifunctional protein that encapsidates the viral genome and functions as an adapter between the virus and the host cell machinery. NPs contain two nuclear localization signals (NLSs): a well-studied monopartite NLS1 and a less-characterized NLS2, thought to be bipartite. The nucleocapsid is a complex of the viral nucleoprotein, RNA, and several other viral proteins. The nucleoprotein forms large, RNA-bound, helical filaments and acts as a scaffold for additional viral proteins.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.

FAQ

Q1-GP蛋白在埃博拉病毒感染中的作用是什么？

GP蛋白介导病毒与宿主细胞受体（如NPC1）的结合和内吞，是中和抗体的主要靶点。
Q2-能否用于假病毒中和实验？

可以，与VP40共表达构建假病毒，评估抗体或药物对病毒入侵的抑制能力。
Q3-如何验证GP蛋白的天然三聚体构象？

通过分子筛色谱和负染电镜分析，确认其形成稳定的三聚体结构。
Q4-是否支持疫苗研发？

支持，作为亚单位疫苗抗原，已在小鼠和非人灵长类模型中验证免疫原性。
Q5-运输和储存条件是什么？

液体需-80℃保存，冻干粉可常温运输，复溶后分装避免反复冻融。

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