Recombinant SARS-CoV-2/COVID-19 Omicron Spike RBD Protein, His tag_天津卡梅德科技发展有限公司

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Recombinant SARS-CoV-2/COVID-19 Omicron Spike RBD Protein, His tag

Recombinant SARS-CoV-2/COVID-19 Omicron Spike RBD Protein, His tag

产品编号

COV444

别名

SARS-CoV-2/COVID-19 Omicron protein, SARS-CoV-2 Spike RBD Protein, recombinant 2019-nCoV S Omicron/B.1.1.529 protein

规格

100ug

DATASHEET MSDS

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产品介绍

Alias	SARS-CoV-2/COVID-19 Omicron protein, SARS-CoV-2 Spike RBD Protein, recombinant 2019-nCoV S Omicron/B.1.1.529 protein
Catalog Number	COV444
Molecular Name	SARS-CoV-2 (B.1.1.529/Omicron)
Species	COVID-19
Host	HEK293 Cells
Size	100ug
Purity	>95%, determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	Less than 1.0 EU per ug by the LAL method.
Formulation	Lyophilized from sterile PBS, pH 7.4.
Background	A novel severe acute respiratory syndrome (SARS)-like coronavirus (SARS-CoV-2) emerged and is rapidly spreading in humans, causing COVID-19. A key to tackling this pandemic is to understand the receptor recognition mechanism of the virus, which regulates its infectivity, pathogenesis and host range. SARS-CoV-2 and SARS-CoV recognize the same receptor—angiotensin-converting enzyme 2 (ACE2)—in humans. Researchers determined the crystal structure of the receptor-binding domain (RBD) of the spike protein of SARS-CoV-2 (engineered to facilitate crystallization) in complex with ACE2. In comparison with the SARS-CoV RBD, an ACE2-binding ridge in SARS-CoV-2 RBD has a more compact conformation, moreover, several residue changes in the SARS-CoV-2 RBD stabilize two virus-binding hotspots at the RBD–ACE2 interface. These structural features of SARS-CoV-2 RBD increase its ACE2-binding affinity. Additionally, we show that RaTG13, a bat coronavirus that is closely related to SARS-CoV-2, also uses human ACE2 as its receptor.
Predicted N Terminus	Arg 319
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.

FAQ

Q1-该RBD蛋白是否覆盖Omicron变异株的关键突变？

是的，包含K417N、E484K、N501Y等突变，模拟Omicron BA.1/BA.2的RBD结构。
Q2-能否用于中和抗体检测？

可以，结合假病毒系统或竞争ELISA，评估抗体对Omicron的中和效力。
Q3-如何验证蛋白的正确折叠？

通过ELISA检测其与ACE2受体及中和抗体的结合能力，确保构象正确。
Q4-是否支持疫苗研发？

支持，作为m疫苗或亚单位疫苗的候选抗原，提供小鼠模型免疫数据。
Q5-运输和储存条件是什么？

液体需-80℃保存，冻干粉可常温运输，复溶后分装避免反复冻融。

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