Mouse Anti HCoV-OC43 Spike Antibody_天津卡梅德科技发展有限公司

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Mouse Anti HCoV-OC43 Spike Antibody

Mouse Anti HCoV-OC43 Spike Antibody

产品编号

SMAG3233

别名

规格

100ul

DATASHEET MSDS

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产品介绍

Catalog Number	SMAG3233
Product Description	This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant CoV spike S1+S2 ECD protein. The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Host	Mouse
Size	100ul
Clonity	Monoclonal
Purification	亲和纯化
Formulation	0.2 μm filtered solution in PBS.
Background	The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2, DPP4, dipeptidyl peptidase-4, APN, aminopeptidase N, CEACAM, carcinoembryonic antigen-related cell adhesion molecule 1, Sia, sialic acid, O-ac Sia, O-acetylated sialic acid. The spike is essential for both host specificity and viral infectivity. The term 'peplomer' is typically used to refer to a grouping of heterologous proteins on the virus surface that function together. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. It's been reported that SARS-CoV-2 (COVID-19 coronavirus, 2019-nCoV) can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion. The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. The main functions for the Spike protein are summarized as: Mediate receptor binding and membrane fusion, Defines the range of the hosts and specificity of the virus, Main component to bind with the neutralizing antibody, Key target for vaccine design, Can be transmitted between different hosts through gene recombination or mutation of the receptor binding domain (RBD), leading to a higher mortality rate.
Application	WB,ELISA
Recommended Dilution	WB 1:1000-1:5000 ELISA 1:1000-1:2000
Tag	Unconjugated
Storage Condition	Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Avoid repeated freeze-thaw cycles.
Shipping Condition	冰袋运输

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