Human respiratory syncytial virus Fusion protein, His tag_天津卡梅德科技发展有限公司

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Human respiratory syncytial virus Fusion protein, His tag

Human respiratory syncytial virus Fusion protein, His tag

产品编号

PA181

别名

F Protein, RSV,HRSVgp08 Protein, RSV

规格

100ug

DATASHEET MSDS

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产品介绍

Alias	F Protein, RSV,HRSVgp08 Protein, RSV
Catalog Number	PA181
Product Description	A DNA sequence encoding the extracellular domain of human respiratory syncytial virus Fusion protein (Met 1-Thr 529) was expressed with a polyhistidine tag at the C-terminus.
Molecular Name	RSV-F
Species	RSV
Host	Baculovirus-Insect Cells
Size	100ug
Purity	> 95 % as determined by SDS-PAGE.
Purification	亲和纯化
Endotoxin	< 1.0 EU per μg protein as determined by the LAL method.
Formulation	Lyophilized from sterile 20mM Tris, 500mM NaCl, pH 7.4, 10% gly.
Background	Human respiratory syncytial virus (HRSV) is the most common etiological agent of acute lower respiratory tract disease in infants and can cause repeated infections throughout life. It is classified within the genus pneumovirus of the family paramyxoviridae. Like other members of the family, HRSV has two major surface glycoproteins (G and F) that play important roles in the initial stages of the infectious cycle. The G protein mediates attachment of the virus to cell surface receptors, while the F protein promotes fusion of the viral and cellular membranes, allowing entry of the virus ribonucleoprotein into the cell cytoplasm. The fusion (F) protein of RSV is synthesized as a nonfusogenic precursor protein (F), which during its migration to the cell surface is activated by cleavage into the disulfide-linked F1 and F2 subunits. This fusion is pH independent and occurs directly at the outer cell membrane, and the F2 subunit was identifed as the major determinant of RSV host cell specificity. The trimer of F1-F2 interacts with glycoprotein G at the virion surface. Upon binding of G to heparan sulfate, the hydrophobic fusion peptide is unmasked and induces the fusion between host cell and virion membranes. Notably, RSV fusion protein is unique in that it is able to interact directly with heparan sulfate and therefore is sufficient for virus infection. Furthermore, the fusion protein is also able to trigger p53-dependent apoptosis.
Tag	HIS
Virus Titer	57.8 kDa
Storage Condition	Store it under sterile conditions at -80℃.
Shipping Condition	冰袋运输

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