Influenza A H5N1 Hemagglutinin, His tag_天津卡梅德科技发展有限公司

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Influenza A H5N1 Hemagglutinin, His tag

Influenza A H5N1 Hemagglutinin, His tag

产品编号

PA163

别名

HA，Hemagglutinin

规格

100ug

DATASHEET MSDS

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产品介绍

Alias	HA，Hemagglutinin
Catalog Number	PA163
Product Description	A DNA sequence encoding the extracellular domain of Influenza A H5N1 Hemagglutinin (Met 1-Gln 527) with cleavage site mutated (RERRRKR→TETR, HA1+HA2, uncleaved) was expressed with a C-terminal polyhistidine tag.
Molecular Name	HA
Species	H5N1
Host	HEK293 Cells
Size	100ug
Purity	> 97 % as determined by SDS-PAGE.
Purification	亲和纯化
Endotoxin	< 1.0 EU per μg protein as determined by the LAL method.
Formulation	Lyophilized from sterile PBS, pH 7.4.
Background	The influenza viral Hemagglutinin (HA) protein is a homotrimer with a receptor binding pocket on the globular head of each monomer.HA has at least 18 different antigens. These subtypes are named H1 through H18.HA has two functions. Firstly, it allows the recognition of target vertebrate cells, accomplished through the binding to these cells' sialic acid-containing receptors. Secondly, once bound it facilitates the entry of the viral genome into the target cells by causing the fusion of the host endosomal membrane with the viral membrane. The influenza virus Hemagglutinin (HA) protein is translated in cells as a single protein, HA, or hemagglutinin precursor protein. For viral activation, hemagglutinin precursor protein (HA) must be cleaved by a trypsin-like serine endoprotease at a specific site, normally coded for by a single basic amino acid (usually arginine) between the HA1 and HA2 domains of the protein. After cleavage, the two disulfide-bonded protein domains produce the mature form of the protein subunits as a prerequisite for the conformational change necessary for fusion and hence viral infectivity.
Tag	His
Virus Titer	75 kDa
Storage Condition	Store it under sterile conditions at -80℃.
Shipping Condition	冰袋运输

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