Mouse IL1A Protein
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产品编号
MOP1129
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别名
IL1A, interleukin 1 alpha, IL1, IL-1A, IL1F1
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规格
- 20ug
- 100ug
- 1mg
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- Mouse IL1A Protein
产品介绍
| Alias | IL1A, interleukin 1 alpha, IL1, IL-1A, IL1F1 |
| Catalog Number | MOP1129 |
| Molecular Name | Interleukin 1 Alpha |
| Species | Mouse |
| Host | E.coli |
| Size | 20ug, 100ug, 1mg |
| Purity | > 90 % as determined by SDS-PAGE |
| Endotoxin | Less than 1EU per ug by the LAL method. |
| Formulation | Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. |
| Background | IL-1 alpha is a member of the interleukin 1 cytokine family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation, and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. Cytokines can be classified into two groups: pro- and anti-inflammatory. Pro-inflammatory cytokines, including IFNgamma, IL-1, IL-6, and TNF-alpha, are predominantly derived from the innate immune cells and Th1 cells. Anti-inflammatory cytokines, including IL-10, IL-4, IL-13, and IL-5, are synthesized from Th2 immune cells. IL-1 alpha is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. It is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. IL-1 alpha stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. |
| Application | SDS-PAGE, WB, ELISA |
| Tag | No Tag |
| Biological Activity | Immobilized mouse IL1A at 10 μg/mL (100 μl/well) can bind mouse IL1R1, The EC50 of mouse IL1R1 is 0.13 μg/mL. |
| Predicted N Terminus | Met |
| Reconstitution | Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
| Storage Condition | Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
| Shipping Condition | In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. |
| Sequence | SAPYTYQSDLRYKLMKLVRQKFVMNDSLNQTIYQDVDKHYLSTTWLND LQQEVKFDMYAYSSGGDDSKYPVTLKISDSQLFVSAQGEDQPVLLKEL PETPKLITGSETDLIFFWKSINSKNYFTSAAYPELFIATKEQSRVHL ARGLPSMTDFQIS |
| Molecular Weight | The mouse IL1A consists of 157 amino acids and migrates as an approximately 18 kDa band in SDS-PAGE under reducing conditions as predicted. |
| Uniprot ID | P01582 |
| Note | 仅供科研使用 |
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