Mouse IL1B Protein
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产品编号
MOP1120
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别名
IL1B, interleukin 1 beta, IL-1, IL1F2, IL1-BETA
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规格
- 20ug
- 100ug
- 1mg
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- Mouse IL1B Protein
产品介绍
| Alias | IL1B, interleukin 1 beta, IL-1, IL1F2, IL1-BETA |
| Catalog Number | MOP1120 |
| Molecular Name | Interleukin 1 beta |
| Species | Mouse |
| Host | E.coli |
| Size | 20ug, 100ug, 1mg |
| Purity | > 95 % as determined by SDS-PAGE |
| Endotoxin | Less than 0.001 ng/ug (0.01 EU/ug) as determined by LAL test. |
| Formulation | Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. |
| Background | Interleukin-1 beta (IL1 beta or IL1B) also known as catabolin, is a member of the interleukin 1 cytokine family. IL1 is a pleiotropic cytokine. It is involved in the inflammatory response, cell growth, and tissue repair in the cortex. The IL1 superfamily consists of three members, IL1A (IL1 alpha), IL1B (IL1 beta), and IL1 receptor antagonist (IL1Ra). In clinical, it has been reported that Interleukin (IL)-1 may influence Th1 / Th2 immune responsiveness and has been implicated in the establishment of a successful pregnancy. Proinflammatory interleukin (IL)-1 gene polymorphisms associated with high levels of IL-1beta activity increase the risk for hypochlorhydria and distal gastric carcinoma. IL1B polymorphisms may be involved in susceptibility to SSc. Moreover, the IL2-384-G allele may be a marker for the limited phenotype of systemic sclerosis (SSc). |
| Application | SDS-PAGE, WB, ELISA |
| Tag | No Tag |
| Biological Activity | Measured by its ability to induce Interferon gamma secretion by human natural killer lymphoma NK-92 cells. The ED50 for this effect is typically 6-30 ng/mL. |
| Predicted N Terminus | Met |
| Reconstitution | Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
| Storage Condition | Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
| Shipping Condition | In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. |
| Sequence | VPIRQLHYRLRDEQQKSLVLSDPYELKALHLNGQNINQQVIFSMSFVQGE PSNDKIPVALGLKGKNLYLSCVMKDGTPTLQLESVDPKQYPKKKMEKRFV FNKIEVKSKVEFESAEFPNWYISTSQAEHKPVFLGNNSGQDIIDFTME SVSS |
| Molecular Weight | The recombinant mouse IL1β consists of 153 amino acids and has a predicted molecular mass of 17.5 kDa. It migrates as an approximately 19 kDa band in SDS-PAGE under reducing conditions as predicted. |
| Uniprot ID | P10749 |
| Note | 仅供科研使用 |
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