Human IL1B Protein
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产品编号
KMPH6334
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别名
IL1B, interleukin 1 beta, IL-1, IL1F2, IL1-BETA
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规格
- 20ug
- 100ug
- 1mg
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- Human IL1B Protein
产品介绍
| Alias | IL1B, interleukin 1 beta, IL-1, IL1F2, IL1-BETA |
| Catalog Number | KMPH6334 |
| Molecular Name | Interleukin 1 beta |
| Species | Human |
| Host | E.coli |
| Size | 20ug, 100ug, 1mg |
| Purity | >95 % as determined by SDS-PAGE. > 95 % as determined by SEC-HPLC |
| Endotoxin | < 5 EU per mg of the protein. |
| Formulation | Supplied as sterile PBS, pH 7.4 |
| Background | Interleukin-1 beta (IL1 beta or IL1B) also known as catabolin, is a member of the interleukin 1 cytokine family. IL1 is a pleiotropic cytokine. It is involved in the inflammatory response, cell growth, and tissue repair in the cortex. The IL1 superfamily consists of three members, IL1A (IL1 alpha), IL1B (IL1 beta), and IL1 receptor antagonist (IL1Ra). In clinical, it has been reported that Interleukin (IL)-1 may influence Th1 / Th2 immune responsiveness and has been implicated in the establishment of a successful pregnancy. Proinflammatory interleukin (IL)-1 gene polymorphisms associated with high levels of IL-1beta activity increase the risk for hypochlorhydria and distal gastric carcinoma. IL1B polymorphisms may be involved in susceptibility to SSc. Moreover, the IL2-384-G allele may be a marker for the limited phenotype of systemic sclerosis (SSc). |
| Application | SDS-PAGE, WB, ELISA |
| Tag | No Tag |
| Biological Activity | Measured by its ability to induce Interferon gamma secretion by human natural killer lymphoma NK-92 cells. The ED50 for this effect is typically 0.2-2 ng/mL. The specific activity of recombinant human IL-1 beta is >60, 000 IU/μg, which is calibrated again |
| Predicted N Terminus | Met |
| Reconstitution | Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
| Storage Condition | Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
| Shipping Condition | In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. |
| Sequence | PVRSLNCTLRDSQQKSLVMSGPYELKALHLQGQDMEQQVVFSMSFVQGEE SNDKIPVALGLKEKNLYLSCVLKDDKPTLQLESVDPKNYPKKKMEKRFVF NKIEINNKLEFESAQFPNWYISTSQAENMPVFLGGTKGGQDITDFTMQ FVSS |
| Molecular Weight | The recombinant human IL1B consists of 154 amino acids and predicts a molecular mass of 17.5 kDa |
| Uniprot ID | P01584 |
| Note | 仅供科研使用 |
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