Mouse IL6 Protein
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产品编号
KMP1881
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别名
白介素-6, IL6, Interleukin-6, BSF2, HSF, IFNB2, IL-6 Protein, Mouse
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规格
- 20ug
- 100ug
- 1mg
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- Mouse IL6 Protein
产品介绍
| Alias | 白介素-6, IL6, Interleukin-6, BSF2, HSF, IFNB2, IL-6 Protein, Mouse |
| Catalog Number | KMP1881 |
| Molecular Name | Interleukin 6, IL 6 |
| Species | Mouse |
| Host | E.coli |
| Size | 20ug, 100ug, 1mg |
| Purity | > 90 % as determined by SDS-PAGE |
| Endotoxin | < 1.0 EU per μg protein as determined by the LAL method. |
| Formulation | Lyophilized from sterile 50mM HAc, pH3.0. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. |
| Background | Interleukin-6 (IL-6) is a multifunctional α-helical cytokine that regulates cell growth and differentiation of various tissues, which is known particularly for its role in the immune response and acute phase reactions. IL-6 protein is secreted by a variety of cell types including T cells and macrophages as a phosphorylated and variably glycosylated molecule. It exerts actions through its heterodimeric receptor composed of IL-6R that lacks the tyrosine/kinase domain and binds IL-6 with low affinity, and ubiquitously expressed glycoprotein 130 (gp130) that binds the IL-6. IL-6R complex with high affinity and thus transduces signals. IL-6 is also involved in hematopoiesis, bone metabolism, and cancer progression, and has been defined as an essential role in directing the transition from innate to acquired immunity. |
| Application | SDS-PAGE, WB, ELISA |
| Tag | No Tag |
| Biological Activity | Measured in a cell proliferation assay using T1165 mouse plasmacytoma cells. The ED50 for this effect is typically 0.1-0.8 ng/mL. |
| Predicted N Terminus | Met |
| Reconstitution | Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
| Storage Condition | Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
| Shipping Condition | In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. |
| Sequence | FPTSQVRRGDFTEDTTPNRPVYTTSQVGGLITHVLWEIVEMRKELCNGNS DCMNNDDALAENNLKLPEIQRNDGCYQTGYNQEICLLKISSGLLEYHSYL EYMKNNLKDNKKDKARVLQRDTETLIHIFNQEVKDLHKIVLPTPISNALL TDKLESQKEWLRTKTIQFILKSLEEFLKVTLRSTRQT |
| Molecular Weight | The recombinant mouse IL6 consists of 188 amino acids and predicts a molecular mass of 21.9 KDa. It migrates as an approximately 22 KDa band in SDS-PAGE under reducing conditions. |
| Uniprot ID | P08505 |
| Note | 仅供科研使用 |
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