Mouse anti Human LAMP1 Monoclonal Antibody_天津卡梅德科技发展有限公司

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Mouse anti Human LAMP1 Monoclonal Antibody

Mouse anti Human LAMP1 Monoclonal Antibody

产品编号

MA1606

别名

CD107a antibody, LAMPA antibody, LGP120 antibody

规格

50ug
100ug

DATASHEET MSDS

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产品介绍

Alias	CD107a antibody, LAMPA antibody, LGP120 antibody
Catalog Number	MA1606
Product Description	The Mouse Anti Human LAMP1 monoclonal Antibody was obtained by affinity purification from a mouse immunized with a purified lysosomal-associated membrane protein 1(120 kDa, P11279)
Host	Mouse
Size	50ug, 100ug
Clonity	Monoclonal
Purity	≥95% as determined by SDS-PAGE
Purification	Affinity purification
Formulation	PBS with 0.02% sodium azide and 50% glycerol pH 7.3
Background	Lysosome associated membrane protein (LAMP1), also known as lgp120 or lgpA, is a type 1 integral membrane protein that is transported from trans Golgi networks to endosomes and then lysosomes. Upon cell activation, LAMP1 transfer to the plasma membrane is dependent on a carboxyl terminal tyrosine based motif (YXXI). Perturbation in the spacing between the tyrosine based motif relative to the membrane abolishes lysosome localization of LAMP1. This mutant protein then cycles between the plasma membrane and the endosome. Cell surface LAMP1 and LAMP2 have been shown to promote adhesion of human peripheral blood mononuclear cells (PBMC) to vascular endothelium, therefore they are possibly involved in the adhesion of PBMCs to the site of inflammation.
Immunogen	lysosomal-associated membrane protein 1(120 kDa, P11279)
Storage Condition	Store at -20℃. Avoid freeze / thaw cycles.
Shipping Condition	This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability	stable at -20 ° C
Cross-reactivity	Human
Product Declaration	本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。

FAQ

Q1- 是否用于溶酶体标记？

是，LAMP1（CD107a）为溶酶体膜标志物，适用于：①免疫荧光（IF）：与LysoTracker共定位验证。②流式细胞术：检测细胞表面LAMP1（激活后易位）。
Q2- 是否区分LAMP1与LAMP2？

特异性结合LAMP1（CD107a），与LAMP2交叉反应率＜0.1%。
Q3- 样本处理建议？

活细胞表面染色需避免透膜；溶酶体定位需甲醇固定及透膜处理。
Q4- 是否支持Western blot？

是，检测约120 kDa糖基化条带，需PNGase F去糖基化验证。
Q5- 保存条件？

液体4℃保存6个月，-20℃保存2年（含50%甘油）。

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